Literature Review: Penggunaan Obat Off-label pada Pasien Pediatri
DOI:
https://doi.org/10.57213/jrikuf.v3i3.682Keywords:
Drug use, Off-label drug, PediatricsAbstract
Off-label drug use is still widely found, especially among vulnerable patients. Pediatrics is one of the vulnerable patient groups who still often get off-label drug therapy. This study was conducted with the aim of looking at the description of the use of off-label drugs given to pediatric patients. This research is a type of research with the literature review method, with data obtained from several articles, the search for articles was carried out through the Google Scholar database. The results of this study from 10 articles used as research data, found the use of off-label drugs in pediatric patients with the most results in the off-label dosage category and followed by off-label dosage category, off-label age category, and off-label route of administration category, while the off-label contraindication category was not found. Based on the results obtained, it is concluded that the use of off-label drugs in pediatric patients is quite high, so it is necessary to monitor the use of off-label drugs to reduce the incidence of unwanted side effects
References
Akbar, R., Setyaningrum, N., & Estiningsih, D. (2017). Kajian penggunaan obat off-label pada anak di Puskesmas Sleman. INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal), 1(1), 21–33.
Anggraini, E. D., Pura, O. N., & Faizah, A. K. (2021). Peresepan obat off-label pada anak dengan penyakit infeksi saluran pernapasan akut. Lumbung Farmasi: Jurnal Ilmu Kefarmasian, 2(1), 5–12.
Ayudia, E., Ersil, V., Sari, N. K., Afriyanti, N., & Merwanta, S. (2022). Gambaran penggunaan obat off-label pada pasien obstetri dan ginekologi. Jurnal Farmasetis, 11(3), 273–278.
Cholisoh, Z., & Rohmah, S. A. (2020). Penggunaan obat off-label dan unlicensed pada bayi dan neonatus di bangsal anak. Pharmacon: Jurnal Farmasi Indonesia, 17(1), 61–69. https://doi.org/10.23917/pharmacon.v17i1.10828
Dera, C. F. A., & Suri, N. (2022). Off-label medication use in pediatric outpatients: A retrospective observational study at Dr. H. Abdul Moeloek Hospital in Lampung. Indonesian Journal of Clinical Pharmacy, 11(2), 116–128. https://doi.org/10.15416/ijcp.2022.11.2.116
Hapsari, R., Aini, S. R., & Hamdin, C. D. (2023). Penggunaan obat off-label pada pasien anak di salah satu rumah sakit daerah Provinsi Nusa Tenggara Barat tahun 2017. Sasambo Journal of Pharmacy, 4(1), 34–37. https://doi.org/10.29303/sjp.v4i1.219
Hidayah, F. N., Iqbal, M., & Wardana, M. F. (2024). Dampak penggunaan obat off-label terhadap adverse drug reactions (ADR) pada pasien pediatri. Jurnal Kesehatan, 14, 1243–1248.
Joharudin, A., Pandanwangi, S., & Lestari, P. (2024). Profil penggunaan obat off-label pada pasien pediatri infeksi saluran pernapasan akut di RSUD Majalengka. Syntax Literate: Jurnal Ilmiah Indonesia, 9(11), 6674–6683.
Mercya, Y., & Ningrum, T. S. (2021). Kajian peresepan obat off-label usia pada pasien pediatri di Rumah Sakit Cahya Kawulayan periode bulan Januari 2021. Jurnal Ilmiah Kefarmasian, 9(2), 82–86.
Ningrum, H. O., Ariyani, H., & Muthaharah, M. (2020). Studi literatur pola penggunaan obat off-label pada pasien obstetri dan ginekologi. JCPS: Journal of Current Pharmaceutical Sciences, 4(1), 273–281. https://journal.umbjm.ac.id/index.php/jcps/article/view/599
Norman, G. A. V. (2023). Off-label use vs off-label marketing of drugs. JACC: Basic to Translational Science, 8(2). https://doi.org/10.1016/j.jacbts.2022.12.011
Putri, I. N., Bahtiar, A., & Andrajati, R. (2021). Pengaruh penggunaan obat on-label dan off-label dengan munculnya reaksi obat tidak dikehendaki pada pasien pediatrik. PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia), 18(1), 138. https://doi.org/10.30595/pharmacy.v18i1.9105
Rahma, N., Susanti, I., Utami, P. R., & Negara, S. B. S. M. K. (2024). Penggunaan obat off-label pada pasien anak di Puskesmas Deket Kecamatan Lamongan. Lumbung Farmasi, 5(1), 17–20.
Setyaningrum, N., Gredynadita, V., & Gartina, S. (2017). Penggunaan obat off-label pada anak di apotek Kota Yogyakarta. Jurnal Sains Farmasi & Klinis, 4(1), 30. https://doi.org/10.29208/jsfk.2017.4.1.169
Taslim, T., Rhinarda, T., & Salim, R. (2020). Gambaran resep obat off-label pasien balita di salah satu apotek swasta Padang periode Januari–April 2017. Jurnal Ilmiah Farmasi, 5(1), [halaman tidak disebutkan].
Tuloli, T. S., Rasdianah, N., Makkulawu, A., Papeo, D. R. P., & Datau, M. (2022). Gambaran penggunaan obat off-label pada pasien pediatrik rawat inap di rumah sakit. Indonesian Journal of Pharmaceutical Education, 2(2), 130–142. https://doi.org/10.37311/ijpe.v2i2.11449
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
