Kandungan Senyawa Fitokimia dan Aktivias Antioksidan dari Ekstrak Daun Alpukat (Persea americana Mill.) : Narrative Review
DOI:
https://doi.org/10.57213/jrikuf.v3i2.597Keywords:
Antioxidant, Extract, Persea americana Leaves, Phytochemical compoundAbstract
Avocado leaves have long been used by Indonesian people as traditional medicine. Many studies have shown that the plant has many active compounds that have the potential to prevent cell damage caused by free radicals. The purpose of this narrative review article is to collect and review references related to the phytochemical compound content and potential antioxidant activity of avocado leaf extract (Persea americana Mill.). The search and review of literature used in writing this article was carried out by searching for reference sources by combining relevant keywords such as "antioxidant AND persea americana leaves* AND extract" on database sites such as NCBI, ScienceDirect, and Google Scholar. There are inclusion criteria used, namely articles in English and Indonesian, available in full text form, discussing secondary metabolite compounds of avocado leaf extract using the maceration method, and discussing antioxidant activity tests using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. Based on the search results, there are 7 articles that have met the inclusion criteria and have been reviewed. The results of this narrative review obtained information that there were several studies that conducted antioxidant activity tests on avocado leaf extract using the DPPH method with an IC50 value range of 6.7-440.80 µg/ml and there were polyphenol compounds, especially quercetin and kaempferol which contributed to the antioxidant activity of avocado leaves.
References
Abd Elkader, A. M., Labib, S., Taha, T. F., Althobaiti, F., Aldhahrani, A., Salem, H. M., Saad, A., & Ibrahim, F. M. (2022). Phytogenic compounds from avocado (Persea americana L.) extracts; antioxidant activity, amylase inhibitory activity, therapeutic potential of type 2 diabetes. Saudi Journal of Biological Sciences, 29(3), 1428–1433. https://doi.org/10.1016/j.sjbs.2021.11.051
Abubakar, A., & Haque, M. (2020). Preparation of medicinal plants: Basic extraction and fractionation procedures for experimental purposes. Asian Journal of Pharmaceutical and Clinical Research, 13(12), 1–10. https://doi.org/10.22159/ajpcr.2020.v13i12.39928
Adiprahara Anggarani, M., Ilmiah, M., & Nasyaya Mahfudhah, D. (2023). Antioxidant activity of several types of onions and its potential as health supplements. Indonesian Journal of Chemical Science, 12(1), 103–111.
Apriani, E. F., Miksusanti, M., Agustiarini, V., Fransiska, O. L., & Hardestyariki, D. (2024). Sambiloto leaf nanoemulsion as a photoprotective agent: Optimization of Tween 20 and PEG-400 concentration using the regular two-level factorial design. International Journal of Applied Pharmaceutics, 16(6), 169–175. https://doi.org/10.22159/ijap.2024v16i6.00000
Aryal, S., Baniya, M. K., Danekhu, K., Kunwar, P., Gurung, R., & Koirala, N. (2019). Total phenolic content, flavonoid content and antioxidant potential of wild vegetables from western Nepal. Plants, 8(4), 96. https://doi.org/10.3390/plants8040096
Asghar, N., Naqvi, S. A. R., Hussain, Z., Rasool, N., Khan, Z. A., Shahzad, S. A., Sherazi, T. A., Janjua, M. R. S. A., Nagra, S. A., Zia-Ul-Haq, M., & Jaafar, H. Z. (2016). Compositional difference in antioxidant and antibacterial activity of all parts of the Carica papaya using different solvents. Chemistry Central Journal, 10(1), 5. https://doi.org/10.1186/s13065-016-0141-6
Awaad, M. M., Mahmoud, E. A. M., Khalil, E. M., & Hanafy, E. A. (2023). Biochemical assessment of Persea americana leaves extracts: Antioxidant, antimicrobial and cytotoxic effects. Egyptian Journal of Chemistry, 66(5), 169–179. https://doi.org/10.21608/ejchem.2022.166538.5397
Boccellino, M. (2023). Health effects of natural antioxidants. International Journal of Molecular Sciences, 24(13), 10395. https://doi.org/10.3390/ijms241310395
Castro-López, C., Bautista-Hernández, I., González-Hernández, M. D., Martínez-Ávila, G. C. G., Rojas, R., Gutiérrez-Díez, A., Medina-Herrera, N., & Aguirre-Arzola, V. E. (2019). Polyphenolic profile and antioxidant activity of leaf purified hydroalcoholic extracts from seven Mexican Persea americana cultivars. Molecules, 24(173), 1–18. https://doi.org/10.3390/molecules24010173
Chaudhary, P., Janmeda, P., Docea, A. O., Yeskaliyeva, B., Abdull Razis, A. F., Modu, B., Calina, D., & Sharifi-Rad, J. (2023). Oxidative stress, free radicals and antioxidants: Potential crosstalk in the pathophysiology of human diseases. Frontiers in Chemistry, 11, 1145596. https://doi.org/10.3389/fchem.2023.1145596
Fatmawaty, Anggreni, N. G. M., Fadhil, N., & Prasasty, V. D. (2019). Potential in vitro and in vivo antioxidant activities from Piper crocatum and Persea americana leaf extracts. Biomedical and Pharmacology Journal, 12(2), 949–955. https://doi.org/10.13005/bpj/1708
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023). Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging. Archives of Toxicology, 97(10), 3053–3125. https://doi.org/10.1007/s00204-023-03588-4
Kingne, F. K., Djikeng, F. T., Tsafack, H. D., Karuna, M. S. L., & Womeni, H. M. (2019). Phenolic content and antioxidant activity of young and mature mango (Mangifera indica) and avocado (Persea americana) leave extracts. International Journal of Phytomedicine, 10(4), 181–193.
Kumar, B., & Cumbal, L. (2016). UV-Vis, FTIR and antioxidant study of Persea americana (avocado) leaf and fruit: A comparison. Revista de La Facultad de Ciencias Químicas, 14, 13–20.
Meo, S., & Venditti, P. (2020). Evolution of the knowledge of free radicals and other oxidants. Oxidative Medicine and Cellular Longevity, 2020, 9829176. https://doi.org/10.1155/2020/9829176
Olasunkanmi, A. M., & Ogunyemi, O. (2023). Phytochemical constituents and antioxidant activity of Persea americana leaves. International Journal of Chemistry Research, 7(3), 1–4.
Polat Kose, L., Bingol, Z., Kaya, R., Goren, A. C., Akincioglu, H., Durmaz, L., Koksal, E., Alwasel, S. H., & Gülçin, İ. (2020). Anticholinergic and antioxidant activities of avocado (Folium perseae) leaves–Phytochemical content by LC-MS/MS analysis. International Journal of Food Properties, 23(1), 878–893. https://doi.org/10.1080/10942912.2020.1762539
Rahmah, R., Putri Rahayu, Y., & Sartika Daulay, A. (2023). Skrining fitokimia dan uji aktivitas antioksidan ekstrak etanol daun alpukat (Persea americana Mill.) dengan metode DPPH. Journal of Pharmaceutical and Sciences, 1(1), 9–25.
Septiawan, A. N., Emelda, E., & Husein, S. (2021). Aktivitas antioksidan kombinasi ekstrak etanol lidah buaya (Aloe vera L.) dan ganggang hijau (Ulva lactuca L.). INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal), 4(1), 11–18.
Sidiropoulou, G. A., Metaxas, A., & Kourti, M. (2023). Natural antioxidants that act against Alzheimer’s disease through modulation of the NRF2 pathway: A focus on their molecular mechanisms of action. Frontiers in Endocrinology, 14, 1229027. https://doi.org/10.3389/fendo.2023.1229027
Solís-Salas, L. M., Sierra-Rivera, C. A., Cobos-Puc, L. E., Ascacio-Valdés, J. A., & Silva-Belmares, S. Y. (2021). Antibacterial potential by rupture membrane and antioxidant capacity of purified phenolic fractions of Persea americana leaf extract. Antibiotics, 10(5), 495. https://doi.org/10.3390/antibiotics10050495
Utami, Y. P., Yulianty, R., Djabir, Y. Y., & Alam, G. (2024). Antioxidant activity, total phenolic and total flavonoid contents of Etlingera elatior (Jack) R.M. Smith from North Luwu, Indonesia. Tropical Journal of Natural Product Research, 8(1), 5955–5961. https://doi.org/10.26538/tjnpr/v8i1.904
Wiyono, E. A., Rukmasari, D., Ruriani, E., Herlina, Aryani, T., Aulia, I., Mu, U., Amalia, L., Masyarakat, D. G., Manusia, F. E., Maharani, A. I., Riskierdi, F., Febriani, I., Kurnia, K. A., Rahman, N. A., Ilahi, N. F., Farma, S. A., Pratiwi, A., Yusran, & Lestari, K. (2023). Karakteristik mutu serbuk pewarna buah naga merah (Hylocereus polyrhizus) hasil foam mat drying dengan variasi rasio daging dan kulit buah. Prosiding Seminar Nasional Bio, 17(2), 171–178.
Zeb, A. (2020). Concept, mechanism, and applications of phenolic antioxidants in foods. Journal of Food Biochemistry, 44(9), e13394. https://doi.org/10.1111/jfbc.13394
Zhang, Q. W., Lin, L. G., & Ye, W. C. (2018). Techniques for extraction and isolation of natural products: A comprehensive review. Chinese Medicine, 13(1), 20. https://doi.org/10.1186/s13020-018-0177-x
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