Potensi Herbal Medicine dalam Pencegahan Gangguan Menstruasi dan Sindrom Premenstrual : Kajian Literatur Sistematik

Fransiska Mochtar; Saddam Muhdi; Yessi Rahayu; Ami Amelia

doi:10.57213/tjghpsr.v1i3.614

Authors

Fransiska Mochtar Universitas Abdurrab
Saddam Muhdi Universitas Abdurrab
Yessi Rahayu Universitas Abdurrab
Ami Amelia Universitas Abdurrab

DOI:

https://doi.org/10.57213/tjghpsr.v1i3.614

Keywords:

clinical trials, herbal medicine, menstrual disorders, premenstrual syndrome, prevention

Abstract

Menstrual disorders and premenstrual syndrome (PMS) are common gynecological conditions that significantly impact women's quality of life and productivity. Herbal medicine, used both traditionally and supported by scientific evidence, offers a promising preventive approach. This study aims to systematically evaluate the effectiveness of herbal medicine in preventing menstrual disorders and PMS. A systematic literature search was conducted following the PRISMA 2020 guidelines using databases such as PubMed, Scopus, ScienceDirect, and the Cochrane Library for articles published between January 2013 and December 2023. Out of 1,143 articles identified, 26 studies met the inclusion criteria. The most frequently studied herbs included Vitex agnus-castus, Zingiber officinale, Curcuma longa, and Foeniculum vulgare. Several randomized controlled trials reported significant improvements in PMS symptoms and menstrual cycle regulation. These findings support the potential of herbal medicine as an effective preventive strategy; however, further high-quality clinical trials with standardized preparations and long-term follow-up are needed for clinical validation.

References

Armanini, D., Karbowiak, I., Funder, J. W., et al. (2003). Licorice and hormone levels. The Lancet, 362(9379), 1233–1234. https://doi.org/10.1016/S0140-6736(03)14513-7

Bahrami, M., et al. (2016). The effect of Vitex agnus-castus on premenstrual syndrome: A systematic review. Journal of Psychosomatic Obstetrics & Gynecology, 37(3), 111–117. https://doi.org/10.3109/0167482X.2016.1149154

Cases, J., Ibarra, A., Feuillère, N., Roller, M., & Sukkar, S. G. (2011). Pilot trial of Melissa officinalis L. leaf extract in the treatment of mild-to-moderate anxiety disorders and sleep disturbances. Mediterranean Journal of Nutrition and Metabolism, 4(3), 211–218. https://doi.org/10.1007/s12349-010-0045-4

Daily, J. W., Yang, M., & Park, S. (2016). Efficacy of turmeric extracts and curcumin for alleviating the symptoms of joint arthritis: A systematic review and meta-analysis of randomized clinical trials. Journal of Medicinal Food, 19(8), 717–729. https://doi.org/10.1089/jmf.2016.3705

Direkvand-Moghadam, A., Sayehmiri, K., Delpisheh, A., & Kaikhavani, S. (2014). Epidemiology of premenstrual syndrome (PMS)—A systematic review and meta-analysis study. Journal of Clinical and Diagnostic Research, 8(2), 106–109. https://doi.org/10.7860/JCDR/2014/8024.4026

Ekor, M. (2014). The growing use of herbal medicines: Issues relating to adverse reactions and challenges in monitoring safety. Frontiers in Pharmacology, 4, 177. https://doi.org/10.3389/fphar.2013.00177

Hajhashemi, V., et al. (2009). Anti-inflammatory and analgesic properties of Curcuma longa extract. Journal of Ethnopharmacology, 124(1), 20–24. https://doi.org/10.1016/j.jep.2009.03.035

Lauche, R., Cramer, H., Häuser, W., Dobos, G., & Schneider, A. (2016). A systematic overview of reviews for complementary and alternative therapies in the treatment of the premenstrual syndrome. European Journal of Integrative Medicine, 8(1), 17–29. https://doi.org/10.1016/j.eujim.2015.08.004

Lete, I., & Allué, J. (2016). Dismenorrhea: Epidemiology, diagnosis and treatment. Drugs in Context, 5, 212291. https://doi.org/10.7573/dic.212291

Marjoribanks, J., Ayeleke, R. O., Farquhar, C., & Proctor, M. (2015). Nonsteroidal anti-inflammatory drugs for dysmenorrhoea. Cochrane Database of Systematic Reviews, (7). https://doi.org/10.1002/14651858.CD001751.pub3

Modarresi, M., et al. (2018). Effect of Foeniculum vulgare on the severity of PMS. Complementary Therapies in Clinical Practice, 31, 79–83. https://doi.org/10.1016/j.ctcp.2018.01.006

Namavar Jahromi, B., Tartifizadeh, A., & Khabnadideh, S. (2011). Comparison of fennel and mefenamic acid for the treatment of primary dysmenorrhea. International Journal of Gynecology & Obstetrics, 112(3), 210–213. https://doi.org/10.1016/j.ijgo.2010.09.021

Nejatbakhsh, F., et al. (2015). Complementary medicine in gynecology: A review on herbal approaches in Iranian Traditional Medicine. Iranian Journal of Medical Sciences, 40(4), 202–209.

Osayande, A. S., & Mehulic, S. (2014). Diagnosis and initial management of dysmenorrhea. American Family Physician, 89(5), 341–346.

Ozgoli, G., Goli, M., & Simbar, M. (2009). Effects of ginger capsules on pain and menstrual bleeding in primary dysmenorrhea. The Journal of Alternative and Complementary Medicine, 15(2), 129–132. https://doi.org/10.1089/acm.2008.0311

Rahnama, P., et al. (2012). Effect of Zingiber officinale on primary dysmenorrhea. Journal of Alternative and Complementary Medicine, 18(8), 776–780. https://doi.org/10.1089/acm.2011.0153

Sliutz, G., Speiser, P., Schultz, A. M., Spona, J., & Zeillinger, R. (1993). Agnus castus extracts inhibit prolactin secretion of rat pituitary cells. Hormone and Metabolic Research, 25(5), 253–255. https://doi.org/10.1055/s-2007-1002021