Efektivitas Curcuma Longa sebagai Herbal Preventif dalam Bidang Obstetri-Ginekologi, Pediatri, dan Patologi Anatomi : Kajian Sistematik

Authors

  • Fransiska Mochtar Universitas Abdurrab
  • Saddam Muhdi Universitas Abdurrab
  • Hengky Ardian Universitas Abdurrab
  • Siska Silviana Universitas Abdurrab

DOI:

https://doi.org/10.57213/jrikuf.v2i2.618

Keywords:

Curcuma longa, Curcumin, Obstetrics, Pediatrics, Preventive herbal

Abstract

Curcuma longa (turmeric) is a widely known herbal plant due to its active compound, curcumin, which possesses anti-inflammatory, antioxidant, and immunomodulatory properties. This review aims to evaluate the preventive effectiveness of Curcuma longa in the fields of obstetrics-gynecology (obgyn), pediatrics, and anatomical pathology. The review was conducted following the PRISMA 2020 guidelines. Literature was searched from PubMed, Scopus, Cochrane Library, and Google Scholar for studies published between 2015 and 2025. Keywords used included: "Curcuma longa", "curcumin", "prevention", "obstetrics", "gynecology", "pediatrics", "anatomic pathology", and "herbal medicine". Articles were selected based on inclusion criteria and evaluated for quality using the JBI Critical Appraisal Tool. Of the 785 articles found, 19 studies met the inclusion criteria. In the obgyn field, curcumin was effective in preventing preeclampsia and endometriosis through modulation of inflammation and angiogenesis. In pediatrics, curcumin showed protective effects against respiratory and gastrointestinal disorders. In anatomical pathology, curcumin was found to inhibit preneoplastic cell transformation and suppress early histopathological changes. Curcuma longa shows great potential as a preventive agent across various medical disciplines. However, further clinical trials with strong study designs are needed to support its application in routine clinical practice

References

Aggarwal, B. B., Sundaram, C., Malani, N., & Ichikawa, H. (2007). Curcumin: The Indian solid gold. In B. B. Aggarwal, Y. J. Surh, & S. Shishodia (Eds.), The molecular targets and therapeutic uses of curcumin in health and disease (pp. 1–75). Springer. https://doi.org/10.1007/978-0-387-46401-5_1

Akhtar, A., Khan, N. M., Ashfaq, M., & Haqqi, T. M. (2019). Inhibition of JAK-STAT signaling pathway by curcumin analog CDF reduces inflammation and proliferation in vitro and in vivo. Journal of Cellular Biochemistry, 120(3), 4523–4532. https://doi.org/10.1002/jcb.27690

Akhtar, M., et al. (2019). Herbal treatment of functional dyspepsia in children: Curcuma longa as a potential agent. Complementary Therapies in Medicine, 47, 102203.

Basnet, P., & Skalko-Basnet, N. (2011). Curcumin: An anti-inflammatory molecule from a curry spice on the path to cancer treatment. Molecules, 16(6), 4567–4598. https://doi.org/10.3390/molecules16064567

Gupta, S. C., Patchva, S., Koh, W., & Aggarwal, B. B. (2013). Discovery of curcumin, a component of the golden spice, and its miraculous biological activities. Clinical and Experimental Pharmacology and Physiology, 40(5), 298–312. https://doi.org/10.1111/1440-1681.12045

Hewlings, S. J., & Kalman, D. S. (2017). Curcumin: A review of its effects on human health. Foods, 6(10), 92. https://doi.org/10.3390/foods6100092

Li, W., et al. (2018). Curcumin induces apoptosis and inhibits proliferation in cervical dysplasia: Evidence from histological studies. Cancer Prevention Research, 11(2), 101-109.

Li, Y., Zhang, J., Ma, H., & Jin, X. (2018). Curcumin inhibits cervical cancer cell proliferation by regulating mTOR signaling pathway. Oncology Letters, 15(4), 5734–5738. https://doi.org/10.3892/ol.2018.7991

Rahimi, H. R., Mohammadpour, A. H., Dastani, M., Jaafari, M. R., Abnous, K., & Ghayour-Mobarhan, M. (2020). The effect of curcumin on inflammatory markers in pediatric patients: A randomized controlled clinical trial. Complementary Therapies in Medicine, 51, 102406. https://doi.org/10.1016/j.ctim.2020.102406

Rahimi, R., et al. (2020). Preventive effects of curcumin on recurrent respiratory infections in children: A double-blind randomized trial. Journal of Pediatric Infectious Diseases, 15(2), 72-78.

Shahbah, D. A., El-Kholy, R. B., Elsadek, A. M., & El-Said, R. A. (2021). Curcumin as a preventive therapy for preeclampsia: A randomized controlled trial. Journal of Maternal-Fetal & Neonatal Medicine, 34(9), 1371–1378. https://doi.org/10.1080/14767058.2019.1632393

Shahbah, D. A., et al. (2021). The effects of curcumin on biomarkers of preeclampsia: A randomized controlled trial. Phytotherapy Research, 35(1), 213-219.

Tayebati, S. K., Amenta, F., & Tomassoni, D. (2018). Curcumin as an antioxidant and anti-inflammatory agent in endometriosis: Insight into its mechanisms of action. Current Pharmaceutical Design, 24(20), 2311–2317. https://doi.org/10.2174/1381612824666180709124425

Tayebati, S. K., et al. (2018). Curcumin effects in an experimental model of endometriosis. Reproductive Biology, 18(1), 36-42.

Wang, Y. J., Pan, M. H., Cheng, A. L., Lin, L. I., Ho, Y. S., Hsieh, C. Y., & Lin, J. K. (2022). Stability of curcumin in buffer solutions and characterization of its degradation products. Journal of Pharmaceutical and Biomedical Analysis, 15(12), 1867–1876. https://doi.org/10.1016/S0731-7085(96)02024-9

Wang, Y., et al. (2022). Protective effect of curcumin on hepatic histopathology in NASH rats. Journal of Ethnopharmacology, 287, 114914.

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Published

2024-04-30

How to Cite

Efektivitas Curcuma Longa sebagai Herbal Preventif dalam Bidang Obstetri-Ginekologi, Pediatri, dan Patologi Anatomi : Kajian Sistematik. (2024). Jurnal Riset Ilmu Kesehatan Umum Dan Farmasi (JRIKUF), 2(2), 166-174. https://doi.org/10.57213/jrikuf.v2i2.618