Studi Penggunaan Obat pada Pasien Gastroesophageal Reflux Disease (GERD) Rawat Jalan di RS. Aura Syifa Kediri Periode Januari - November 2022

Fitria Wahyuning Wulan; Mellinnia Lailla Sari

doi:10.57213/jrikuf.v2i3.289

Authors

Fitria Wahyuning Wulan Bhakti Wiyata Kediri
Mellinnia Lailla Sari Bhakti Wiyata Kediri

DOI:

https://doi.org/10.57213/jrikuf.v2i3.289

Keywords:

Gastroesophageal Reflux Disease (GERD), Proton Pump Inhibitor (PPI), Drug Use Studies

Abstract

Background: Gastroesophageal Reflux Disease (GERD) is a pathological condition caused by reflux of contents from the stomach entering the esophagus, with various signs and symptoms involving the esophagus, pharynx, larynx and airway. Gastroesophageal Reflux Disease (GERD) has typical symptoms of heartburn and regurgitation. So that the symptoms that appear will interfere with all activities carried out by someone. Objective: This study is to determine the profile picture of drug use in outpatient Gastroesophageal Reflux Disease (GERD) patients at Aura Syifa Hospital Kediri and to determine the study of drug use in outpatient Gastroesophageal Reflux Disease (GERD) patients at Aura Syifa Hospital Kediri by analyzing the right indications and right doses. Method: This study is a descriptive observational study with retrospective data collection from patient medical record data. Results: The results of a study on the useof drugs in outpatient gastroesophageal reflux disease (GERD) patients at Aura Syifa Hospital Kediri for the period January-November 2022 by analyzing the right indications and correct doses, which were obtained as many as 175 patients. The most GERD patients were women as many as 114 patients and men as many as 61 patients. The most common age for GERD is 56-65 years old and >65 years old. The most widely used drug class is the Proton Pump Inhibitor (PPI) class with a percentage of 38% and the drug in this class that is often used is lansoprazole with 167 prescriptions. The results of a study on drug use in outpatient gastroesophageal reflux disease (GERD) patients at Aura Syifa Hospital Kediri for the period January- November 2022 that meet the rationality of treatment based on the literature of the Indonesian GERD Consensus in 2013 or BNF 2017 or Pharmacotherapy A Pathophysiologic Approach 11^th edition in 2020 or Medscape, where the indication is 100% (175 patients) and the right dose is 100% (175 patients).

References

Aisiyah, N., Akib Yuswar, M., & Purwanti, N.

U. (2022). Rasionalitas Penggunaan Obat Pada Pasien GERD di Instalasi Rawat Jalan Rumah Sakit. Journal Syifa Sciences and Clinical Research (JSSCR), 4.https://doi.org/10.37311/jsscr.v4i3.153 64.

Alldredge, B.K., Corelli, R.L., Ernst, M.E., Guglielmo, B.J., Jacobson, P.A., Kradjan, W.A., & Williams B.R. (2013). Koda-Kimble & Young’s Applied Therapeutics: The ClinicalUse of Drugs, 10th ed., LiPPIncott Williams & Wilkins, Pennsylvania, United States of America.

British National Formulary(BNF). (2017). 73th ed., Royal Pharmaceutical Society: London.

Darnindro, N., Manurung, A., Mulyana, E., & Harahap, A. (2018). Prevalence of Gastroesophageal Reflux Disease (GERD) in Dyspepsia Patients in Primary Referral Hospital (Vol. 19, Issue 2).

Dipiro, J., Yee, G., Posey, L., Haines, S., Nolin, T., & Ellingrod , V. (2020). Pharmacotherapy a Pathophysiologic Approch 11th Edition. The McGraw Hill Companies: United States.

Dipiro, J.T., Talbert, R.L., Yee, G.C., M., & G.R., Wells, B, G., dan Posey, L. (2016). Pharmacotherapy A Phatophysiologic Approach (10th Edition). 289-290. Mc Graw-Hill Companies: United State.

Direktorat Bina Pelayanan Kefarmasian. (2011). Modul Penggunaan Obat Rasional. Jakarta, Indonesia: Kementerian Kesehatan RI.

El-Serag, H. B., Sweet, S., Winchester, C. C., & Dent, J. (2014). Update on the epidemiology of gastro-oesophageal reflux disease: A systematic review. In Gut (Vol. 63, Issue 6, pp. 871–880). BMJ Publishing Group. https://doi.org/10.1136/gutjnl-2012- 304269.

Friyanto, D., & Lestari, S. (2019). Analisis Penggunaan Obat Gastroesophageal Reflux Disease (GERD) Pada Pasien Rawat Jalan di Rumah Sakit Umum Daerah Karawang. Pharma Xplore: Jurnal Sains dan Ilmu Farmasi, 4(1), 240- 247.

Katzung, B.G., Masters, S.B., dan Trevor, A.J. (2014). Farmakologi Dasar & Klinik, Vol.2, Edisi 12, Editor Bahasa Indonesia Ricky Soeharsono et al. Jakarta: Penerbit Buku Kedokteran EGC.

Khodarahmi, M., Azadbakht, L., Daghaghzadeh, H., Feinle-Bisset, C., Keshteli, A. H., Afshar, H., Feizi, A., Esmaillzadeh, A., & Adibi, P. (2016). Evaluation of the relationship between major dietary patterns and uninvestigated reflux among Iranian adults. Nutrition, 32(5), 573–583. https://doi.org/10.1016/J.NUT.2015.11. 012.

MacFarlane, B. (2018). Management of gastroesophageal reflux disease in adults: a pharmacist perspective. Integrated Pharmacy Research and Practice, Volume 7, 41–52. https://doi.org/10.2147/iprp.s142932.

Medscape. Drug and Disease. Available from URL: http://reference.medscape.com.

Ndraha, S., Oktavius, D., Leonard Sumampouw, J., Nyoman Juli, N., & Marcel, R. (2016). Faktor-Faktor yang Berhubungan dengan Keberhasilan Terapi GERD. Artikel Penelitian. In J. Kedokt Meditek (Vol. 22, Issue 60).

Rahman, A., Maulidina, W., & Kosasih, E. D. (2018). Gambaran Terapi Awal Pada Pasien GERD (Gastroesophageal Initial Therapy For GERD (Gastroesophageal Reflux Disease) Patients In Internist Departement Of Rsud Dr. Soekardjo. 2(6), Jurnal Kesehatan Poltekkes Kemenkes RI Pangkal Pinang, 69–76.

Santika, N. Y., Desnita, R., & Akib Yuswar, M. (2019). Evaluasi Penggunaan Obat Tukak Peptik pada Pasien Tukak Peptik di Instalasi Rawat Inap RSUD Sultan Syarif Mohamad Alkadrie Pontianak Evaluation of Peptic Ulcer Medication Use in Patients with Peptic Ulcer at Inpatient Installation RSUD Sultan Syarif Mohamad Alkadrie. 15(1), 1–15.

Sudoyo AW, Setiyohadi B, Alwi I, Simadibrata M, Setiati S. (2009). Buku Ajar Ilmu Penyakit Dalam Jilid II edisi V. Jakarta: Interna Publishing.

Syam, A. F., Aulia, C., Renaldi, K., Simadibrata, M., Abdullah, M., & Tedjasaputra, T. R. (2013). Revisi Konsensus Nasional Penatalaksanaan Penyakit Refluks Gastroesofageal (Gastroesophageal Reflux Disease/GERD) di Indonesia. Jakarta: Perkumpulan Gastroenterologi Indonesia (PGI).

Syam, A. F., Hapsari, P. F., & Makmun, D. (2016). The Prevalence and Risk Factors of GERD among Indonesian Medical Doctors. Makara Journal of Health Research, 20(2). https://doi.org/10.7454/msk.v20i2.5740.

Tarigan, R. C., & Pratomo, B. (2019). Analisis Faktor Risiko Gastroesofageal Refluksdi RSUD Saiful Anwar Malang Gastroesophageal Reflux Risk Factor Analysis at Saiful Anwar Hospital in Malang. In Jurnal Penyaki Dalam Indonesia. (Vol. 6, Issue 2).

Tjay, H.T., dan Rahardjo, K. (2015). Obat-Obat Penting, Edisi VII, Jakarta: PT. Gramedia.

United States Pharmacopeial Convention. Simethicone emulsion. (2013). United States Pharmacopeial Convention: Interim Revision Announcement Official 1 January 2014.