Potensi Jus Buah Pare (Momordica Charantia L.) dalam Menurunkan Kadar Trigliserida pada Tikus Galur Wistar yang Diinduksi Diet Tinggi Lemak

Rindi Ariska Silalahi; Ilham Hariaji

doi:10.57213/tjghpsr.v2i4.476

Authors

Rindi Ariska Silalahi Universitas Muhammadiyah Sumatera Utara
Ilham Hariaji Universitas Muhammadiyah Sumatera Utara

DOI:

https://doi.org/10.57213/tjghpsr.v2i4.476

Keywords:

Cholesterol, Triglycerides, Bitter Melon

Abstract

Hypercholesterolemia is one of the main factors that contribute to the development of life-threatening cardiovascular diseases. Bitter melon (Momordica charantia L.) is known to contain antioxidant compounds that have the potential to reduce cholesterol and triglyceride levels, making it an alternative natural treatment for hyperlipidemia. This study aims to evaluate the effectiveness of bitter melon juice in reducing triglyceride levels in Wistar rats induced by high-fat feed. This study used a true experimental design with a pretest-posttest with control group design. A total of 24 Wistar rats were induced with high-fat feed and divided into four groups: negative control, positive control, treatment group 1 (given bitter melon juice 1.8 mL), and treatment group 2 (given bitter melon juice 2.7 mL). Data analysis was performed using paired t test... A significant decrease in triglyceride levels was found in the groups given bitter melon juice 1.8 mL (p < 0.003) and 2.7 mL (p < 0.001) compared to the control group. Higher doses showed greater effectiveness in reducing triglyceride levels... Bitter melon (Momordica charantia L.) juice was shown to be effective in reducing triglyceride levels in Wistar rats induced by high-fat diet. These findings support the potential of bitter melon as a natural intervention to manage hyperlipidemia..

References

Fan, M., Kim, E. K., Choi, Y. J., Tang, Y., & Moon, S. H. (2019). The role of Momordica charantia in resisting obesity. International Journal of Environmental Research and Public Health, 16(18). https://doi.org/10.3390/ijerph16183251

Marrelli, M., Conforti, F., Araniti, F., & Statti, G. A. (2016). Effects of saponins on lipid metabolism: A review of potential health benefits in the treatment of obesity. Molecules, 21(10). https://doi.org/10.3390/molecules21101404

McRae, M. P. (2008). Vitamin C supplementation lowers serum low-density lipoprotein cholesterol and triglycerides: A meta-analysis of 13 randomized controlled trials. Journal of Chiropractic Medicine, 7(2), 48–58. https://doi.org/10.1016/j.jcme.2008.01.002

Pekerti, A. C., Nila, K. F., & Inggita, K. (2018). Jus jambu merah dan jeruk siam menurunkan trigliserida pada wanita dislipidemia. Indonesian Journal of Human Nutrition, 5(2), 125–130. https://doi.org/10.21176/un.ijhn.2019.006.01.1

Pratama, A. N. (2019). Potensi antioksidan buah pare (Momordica charantia L.) terhadap dislipidemia. Jurnal Ilmiah Kesehatan Sandi Husada, 10(2), 304–310.

Purnamasari, A. W., & Isnawati, M. (2014). Pengaruh pemberian jus pare (Momordica charantia L.) dan jus jeruk nipis (Citrus aurantifolia) terhadap kolesterol total tikus Sparague Dawley. Jurnal Nutrisi dan Kesehatan Masyarakat, 3(4). Retrieved from http://ejournal-s1l.undip.ac.id/index.php/jnc

Purwantiningrum, D. A., Cahayani, W. A., Rahayu, I. D., Ratnaningrum, S. D., & Wijayanto, F. H. (2021). Perbedaan tingkat pengetahuan dan pola perilaku pencegahan dislipidemia pada masyarakat selama pandemi Covid-19. Jurnal TRI DHARMA, 1(2), 104–114. Retrieved from https://jtridharma.ub.ac.id/index.php/jtridharma

Rahmawati, N. D., & Dewi Sartika, R. A. (2020). Analisis faktor-faktor risiko kejadian dislipidemia pada karyawan pria head office PT. X, Cakung, Jakarta Timur. Nutrire Diaita, 12(1), 1–9. https://doi.org/10.47007/nut.v12i01.3014

Rohajatien, U., Harijono, Estiasih, T., & Wahyuni, S. E. (2018). Bitter melon (Momordica charantia L.) fruit decreased blood glucose level and improved lipid profile of streptozotocin-induced hyperglycemia rats. Current Research in Nutrition and Food Science, 6(2), 359–370. https://doi.org/10.12944/CRNFSJ.6.2.11

Santosa, W. N., & Baharuddin, B. (2020). Penyakit jantung koroner dan antioksidan. Keluuwih: Jurnal Kesehatan dan Kedokteran, 1(2), 98–103. https://doi.org/10.24123/kesdok.v1i2.2566

Shintawati, R., Hernawati, & Indraswati, D. (2011). Kadar lipid darah mencit betina middle-aged galur Swiss Webster setelah pemberian jus buah pare (Momordica charantia L.). MKV, 43(2), 93–97.

Trisnadi, R. A., Wibowo, J. W., & Thomas, S. (2021). Pengaruh diet tinggi kolesterol terhadap kadar TNF-α. Penelitian Kesehatan Suara Forikes, 12(2), 132–134. https://doi.org/10.33846/sf12205

Zeka, K., Ruparelia, K., Arroo, R., Budriesi, R., & Micucci, M. (2017). Flavonoids and their metabolites: Prevention in cardiovascular diseases and diabetes. Diseases, 5(3), 19. https://doi.org/10.3390/diseases5030019